Description

5-Nitro-2'-Deoxyuridine is a modified nucleoside analog that serves as a critical biochemical building block and research reagent. This compound is valued for its role in studying nucleic acid metabolism, enzyme inhibition, and as a precursor for more complex molecular probes. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in life science and oncology research. The product is supplied to meet the stringent purity requirements of advanced biochemical applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for thymidine kinase and other nucleoside-metabolizing enzymes.
• Antiviral & Anticancer Agent Development: Serves as a key intermediate in the synthesis and evaluation of novel nucleoside analog prodrugs.
• Molecular Biology: Employed in the study of DNA synthesis, repair mechanisms, and as a tool for cell cycle analysis.
• Diagnostic Reagent Manufacturing: Incorporated into kits and assays for research and clinical diagnostic purposes.
• Academic & Pharmaceutical R&D: A fundamental reagent for investigating nucleotide metabolism and developing targeted therapies.

Basic Information

Item	Detail
Product Name	5-Nitro-2'-Deoxyuridine
CAS No.	3106-01-2
Molecular Formula	C9H11N3O6
Molecular Weight	257.20 g/mol
Synonyms	5-Nitro-2'-deoxyuridine; 5-Nitrodeoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-nitropyrimidine-2,4-dione; 5-Nitro-dUrd; 5-Nitrouracil deoxyriboside; 2'-Deoxy-5-nitouridine; 5-NO2-dU; NSC 55497
EINECS	221-459-8

Quality Control

Our 5-Nitro-2'-Deoxyuridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible results in sensitive biochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.