Description

5-Bromocytidine is a halogenated nucleoside analog of cytidine, where a bromine atom is substituted at the 5-position of the pyrimidine ring. This modification is crucial for its role as a key synthetic intermediate and research tool in the development of novel oligonucleotides and pharmaceutical agents. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, medicinal chemistry, and life science research.

Application

• Oligonucleotide Synthesis: A vital building block for the solid-phase synthesis of modified DNA and RNA strands, enabling the study of structure-function relationships.
• Medicinal Chemistry & Drug Discovery: Serves as a precursor in the synthesis of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used to probe enzyme mechanisms, study nucleic acid interactions, and investigate metabolic pathways involving nucleosides.
• Labeling and Detection: Can be incorporated into oligonucleotides for use as probes or for cross-linking studies due to the reactivity of the bromine moiety.
• Academic & Industrial R&D: Fundamental research reagent in universities and biotech companies for developing new therapeutic and diagnostic platforms.

Basic Information

Product Name	5-Bromocytidine
CAS No.	3066-86-2
Molecular Formula	C9H12BrN3O5
Molecular Weight	306.11 g/mol
Synonyms	5-Bromo-1-β-D-ribofuranosylcytosine; 5-Bromo-1-β-D-ribofuranosyl-2-oxo-4-aminopyrimidine; 5-Br-Cytidine; Cytidine, 5-bromo-; 5-Bromocytosine riboside; 4-Amino-5-bromo-1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone
EINECS	221-312-1

Quality Control

Our 5-Bromocytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain quality.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.