Description

Halcinonide is a potent synthetic corticosteroid belonging to the glucocorticoid class, valued for its significant anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for formulators requiring reliable and consistent performance in topical dermatological preparations. It is primarily utilized by the pharmaceutical industry for the development and manufacture of prescription-strength creams, ointments, and lotions intended for the treatment of severe skin conditions such as eczema, psoriasis, and dermatitis.

Application

• Topical Corticosteroid Formulations: Primary API in prescription creams, ointments, gels, and lotions for treating inflammatory skin disorders.
• Dermatological Preparations: Used in compounding pharmacies for customized medication targeting severe eczema, psoriasis, and allergic contact dermatitis.
• Veterinary Medicine: Incorporated into topical treatments for managing inflammatory skin conditions in animals.
• Clinical Research: Serves as a reference standard and active component in pharmacological studies and new formulation development.

Basic Information

Product Name	Halcinonide
CAS No.	3039-35-4
Molecular Formula	C24H32ClFO5
Molecular Weight	454.96 g/mol
Synonyms	Halcinonide; SQ-18566; 21-Chloro-9-fluoro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; Halog; (11β,16α)-21-Chloro-9-fluoro-11,16,17-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
EINECS	221-236-8

Quality Control

Our Halcinonide is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications aligned with major pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.