Description

2-Aminoethoxy-[[5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxy-Phosphinic Acid is a sophisticated nucleotide derivative and a key intermediate in the synthesis of modified oligonucleotides. This compound is critical for research and development in antisense therapy, diagnostic probe development, and advanced molecular biology. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on nucleic acid chemistry and therapeutic applications.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A crucial phosphoramidite or H-phosphonate precursor for creating therapeutic oligonucleotides that target specific RNA sequences.
• Diagnostic Probe Development: Used in the manufacture of labeled probes for techniques like FISH (Fluorescence In Situ Hybridization) and PCR, enhancing specificity and detection.
• siRNA and miRNA Research: Serves as a building block for synthesizing chemically modified small interfering RNA (siRNA) and microRNA (miRNA) analogs to improve stability and efficacy.
• Pharmaceutical Intermediate: An essential raw material in the production chain of nucleotide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: The reactive amino group allows for conjugation with various reporter molecules (e.g., fluorophores, biotin) for tracking and analysis.
• Structural Biology Studies: Employed to introduce specific modifications into DNA/RNA strands to study structure-function relationships and enzyme interactions.

Basic Information

Product Name	2-Aminoethoxy-[[5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxy-Phosphinic Acid
CAS No.	3036-18-8
Molecular Formula	C11H19N4O11P2
Molecular Weight	436.24 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyadenosine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); dA-CE Phosphoramidite (Adenosine); 2'-Deoxyadenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-DMT-2'-dA-3'-CE Phosphoramidite; Deoxyadenosine Phosphoramidite; Adenine Deoxyribonucleoside Phosphoramidite; dA Phosphoramidite; 2'-Deoxyadenosine-3'-phosphoramidite
EINECS	Contact for details

Quality Control

Our production of this high-purity nucleotide intermediate adheres to strict in-process controls and is validated by comprehensive analytical methods. Each batch is released with a detailed Certificate of Analysis (COA) confirming identity, purity, and absence of critical impurities. We support cGMP-compliant manufacturing for pharmaceutical applications and ensure traceability and documentation meet the stringent requirements of research and therapeutic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.