Description

5'-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranosyl 5'-Monophosphate is a key nucleotide intermediate, specifically the ribonucleotide of AICA riboside (AICAR), which plays a fundamental role in purine biosynthesis and cellular energy regulation. This compound is of significant value in biochemical research and pharmaceutical development due to its activity as an AMP-activated protein kinase (AMPK) activator. It is primarily needed by research institutions, pharmaceutical companies, and diagnostic manufacturers for applications in metabolic studies, drug discovery, and as a critical reference standard.

Application

• Biochemical Research: Used as a critical intermediate and substrate in studies of the de novo purine biosynthesis pathway.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control in the production of related nucleoside/nucleotide therapeutics.
• Metabolic Pathway Modulation: Employed in research investigating AMPK activation, cellular energy sensing, and metabolic disorders such as diabetes and obesity.
• Enzymology Studies: Acts as a substrate for enzymes like AICAR transformylase/IMP cyclohydrolase (ATIC) in enzymatic assays.
• Precursor Synthesis: Utilized as a building block in the chemical and enzymatic synthesis of more complex nucleotides and potential drug candidates.
• Diagnostic Reagent Manufacturing: Incorporated into diagnostic kits and assays for monitoring purine metabolism or related enzymatic activities.

Basic Information

Product Name	5'-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranosyl 5'-Monophosphate
CAS No.	3031-94-5
Molecular Formula	C9H15N4O9P
Molecular Weight	354.21 g/mol
Synonyms	AICAR Monophosphate; AICA Ribonucleotide; 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate; 5'-Phosphoryl AICAR; Acadesine 5'-monophosphate; ZMP (5-Aminoimidazole-4-carboxamide ribonucleotide); AICAR 5'-monophosphate; 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl monophosphate
EINECS	Contact for details

Quality Control

Our 5'-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranosyl 5'-Monophosphate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents. We support research and development with material suitable for use as a reference standard, with specifications available to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥95.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.