Description

10-Acetyl Dithranol is a chemically modified derivative of the active pharmaceutical ingredient dithranol (anthralin), featuring an acetyl group at the 10-position. This modification is strategically employed to enhance stability and modulate the biological activity profile of the parent compound. It serves as a critical pharmaceutical intermediate and reference standard in the research and development of dermatological treatments, particularly for psoriasis. Industries requiring high-purity synthetic building blocks for medicinal chemistry will find this compound essential for their advanced projects.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the manufacture of novel dermatological agents and anti-psoriatic drugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of dithranol-based APIs and formulations.
• Medicinal Chemistry Research: Serves as a building block for structure-activity relationship (SAR) studies to develop new therapeutic compounds with improved efficacy and reduced side effects.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral in the multi-step synthesis of complex pharmaceutical molecules targeting skin disorders.
• Biochemical Research: Utilized in studies investigating the mechanisms of action of anthralin derivatives on keratinocyte proliferation and differentiation.

Basic Information

Product Name	10-Acetyl Dithranol
CAS No.	3022-61-5
Molecular Formula	C17H14O3
Molecular Weight	266.29 g/mol
Synonyms	10-Acetyldithranol; 1,8-Dihydroxy-10-acetyl-9(10H)-anthracenone; 10-Acetylanthralin; 10-Acetyl-1,8,9-anthracenetriol; 10-Acetyl-1,8-dihydroxy-9-anthrone; Acetylated Dithranol; 10-Acetyl derivative of Dithranol
EINECS	Contact for details

Quality Control

Every batch of 10-Acetyl Dithranol is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) that detail key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.