Description

6-Thioinosine 2',3',5'-Triacetate is a chemically modified nucleoside derivative, serving as a key protected intermediate in the synthesis of thiopurine analogs. This compound matters for its role in enabling precise chemical transformations, providing researchers and manufacturers with a stable, functionalized building block for advanced pharmaceutical development. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, biotechnology, and fine chemical industries working on nucleoside-based therapeutics and biochemical probes.

Application

• Pharmaceutical Intermediate: A crucial protected precursor in the multi-step synthesis of active thiopurine drug substances and their prodrugs.
• Biochemical Research: Used as a substrate or intermediate in enzymatic studies and metabolic pathway investigations involving purine analogs.
• Antiviral & Anticancer Agent Development: Serves as a building block for creating novel nucleoside analogs with potential therapeutic activity.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial manufacturing of specialized nucleoside compounds.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in API production.

Basic Information

Product Name	6-Thioinosine 2',3',5'-Triacetate
CAS No.	3021-21-4
Molecular Formula	C16H18N4O7S
Molecular Weight	410.40 g/mol
Synonyms	6-Thioinosine 2',3',5'-Tri-O-acetate; 6-Mercaptopurine riboside triacetate; 6-Thio-9-β-D-ribofuranosylpurine 2',3',5'-triacetate; 6-Thioinosine triacetate; 6-MPR triacetate; 9-[(2R,3R,4R,5R)-3,4-Diacetyloxy-5-(acetyloxymethyl)oxolan-2-yl]-6-sulfanylpurine; 6-Thio-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
EINECS	Contact for details

Quality Control

Our 6-Thioinosine 2',3',5'-Triacetate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.