Description

8-Mercaptoadenosine is a modified nucleoside where the hydroxyl group at the 8-position of adenosine is replaced by a thiol group. This structural modification makes it a valuable biochemical tool and a key intermediate in the synthesis of nucleoside analogs and oligonucleotides. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, biochemical studies, and the development of therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving adenosine deaminase and other purine-metabolizing enzymes.
• Oligonucleotide Synthesis: Serves as a modified monomer for introducing thiol functional groups into DNA or RNA sequences for labeling, conjugation, or structural studies.
• Proteomics & Molecular Biology: Employed in affinity chromatography and as a tool for studying RNA structure and protein-nucleic acid interactions.
• Diagnostic Reagent Development: Used in the formulation of assay kits and diagnostic probes.
• Material Science: Potential use in creating functionalized surfaces and nanomaterials via thiol-gold chemistry.

Basic Information

Product Name	8-Mercaptoadenosine
CAS No.	3001-45-4
Molecular Formula	C10H13N5O4S
Molecular Weight	299.31 g/mol
Synonyms	8-Thioadenosine; Adenosine, 8-mercapto-; 8-SH-Ado; 8-Thioladenosine; 6-Amino-8-mercapto-9-β-D-ribofuranosylpurine; 8-Mercapto-9-β-D-ribofuranosyladenine
EINECS	221-104-5

Quality Control

Our 8-Mercaptoadenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.