Description

5-Chloro-2-Fluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 5-chloro-2-fluorobenzoyl moiety, a key structural motif in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro aromatic system contributes to biological efficacy and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for complex organic molecules used in electronic displays and optoelectronic devices.
• Polymer Chemistry: Employed as a monomer or modifying agent to create specialty polymers with specific thermal, chemical, or mechanical properties.
• Dyestuff and Pigment Manufacturing: Acts as an intermediate in the synthesis of complex dyes and high-performance pigments.
• Custom Synthesis & Contract Research: A valuable reagent for research organizations (CROs) and companies engaged in custom chemical synthesis and process development.

Basic Information

Product Name	5-Chloro-2-Fluorobenzoyl Chloride
CAS No.	394-29-6
Molecular Formula	C7H3Cl2FO
Molecular Weight	192.99 g/mol
Synonyms	2-Fluoro-5-chlorobenzoyl chloride; 5-Chloro-2-fluorobenzoic acid chloride; Benzoic acid, 5-chloro-2-fluoro-, chloride; 5-Chloro-2-fluorobenzoylchloride; 394-29-6; 2-Fluor-5-chlorbenzoylchlorid (German); Chlorure de 5-chloro-2-fluorobenzoyle (French)
EINECS	206-900-6

Quality Control

Our 5-Chloro-2-Fluorobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring reliability for critical pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.