Description

3,3,3-Trifluoro-2-(Trifluoromethyl)Propionyl Chloride is a highly fluorinated acid chloride derivative, serving as a critical building block for introducing the perfluoroisopropyl moiety into complex molecules. Its value lies in enabling the synthesis of advanced materials and pharmaceuticals with enhanced stability, lipophilicity, and unique electronic properties. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty polymer industries seeking to develop next-generation fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing active pharmaceutical ingredients (APIs) with fluorinated side chains, improving metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and performance.
• Polymer & Resin Modification: Incorporates fluorinated groups into polymers to impart oil/water repellency, chemical resistance, and low surface energy for coatings and specialty plastics.
• Organic Synthesis Reagent: A versatile acylating agent for introducing the 3,3,3-trifluoro-2-(trifluoromethyl)propionyl group in fine chemical and material science research.
• Fluorinated Surfactant & Lubricant Precursor: Serves as a starting material for synthesizing high-performance fluorosurfactants and lubricants used in demanding industrial applications.

Basic Information

Product Name	3,3,3-Trifluoro-2-(Trifluoromethyl)Propionyl Chloride
CAS No.	382-19-4
Molecular Formula	C5HF6ClO
Molecular Weight	214.50 g/mol
Synonyms	Perfluoroisobutyryl Chloride; 2-(Trifluoromethyl)-3,3,3-trifluoropropanoyl Chloride; 3,3,3-Trifluoro-2-(trifluoromethyl)propanoyl Chloride; Pentafluoroisobutyryl Chloride; PFIB Chloride; 1,1,1,3,3,3-Hexafluoro-2-(chlorocarbonyl)propane; Heptafluoroisobutyryl Chloride (common misnomer); α,α-Bis(trifluoromethyl)acetyl Chloride
EINECS	206-848-5

Quality Control

Our 3,3,3-Trifluoro-2-(Trifluoromethyl)Propionyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and reacts violently with water, strong bases, and alcohols. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Acid Value	Contact for details
Density (20°C)	~1.6 g/mL
Boiling Point	~70-72°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.