Description

6-α-Fluoro-17-Alpha,21-Dihydroxy-16-α-Methylpregn-4-Ene-3,20-Dione is a high-purity synthetic steroid intermediate of significant commercial and research importance. Its core value lies in its role as a critical precursor in the synthesis of potent glucocorticoid and anti-inflammatory pharmaceutical agents, ensuring reliable and scalable production. This compound is essential for manufacturers and R&D laboratories in the global pharmaceutical, biotechnology, and fine chemical sectors focused on advanced steroid chemistry and drug development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent corticosteroid drugs such as dexamethasone and betamethasone.
• Anti-inflammatory Agent Synthesis: Used in research and production of advanced glucocorticoid receptor agonists for treating inflammatory and autoimmune conditions.
• Steroid Chemistry Research: Serves as a fundamental substrate for studying structure-activity relationships (SAR) and developing novel steroid-based therapeutics.
• Fine Chemical Manufacturing: Employed in multi-step organic synthesis for producing high-value, complex steroid molecules.
• Reference Standard: Utilized as an analytical standard in quality control (QC) and regulatory testing for pharmaceutical products.
• Veterinary Pharmaceutical Production: Applied in the formulation of anti-inflammatory treatments for animal health.

Basic Information

Product Name	6-α-Fluoro-17-Alpha,21-Dihydroxy-16-α-Methylpregn-4-Ene-3,20-Dione
CAS No.	378-59-6
Molecular Formula	C22H29FO4
Molecular Weight	376.46 g/mol
Synonyms	9α-Fluoro-11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Acetate Intermediate; 6α-Fluoro-16α-methylprednisolone Intermediate; 6α-Fluoro-16α-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione Precursor; 6-Fluoro-16-methylprednisolone Derivative; Fludrocortisone Acetate Related Compound; 378-59-6; 6α-Fluoro-16α-methyl-δ1,4-pregnadiene-11β,17α,21-triol-3,20-dione Intermediate
EINECS	Contact for details

Quality Control

Our 6-α-Fluoro-17-Alpha,21-Dihydroxy-16-α-Methylpregn-4-Ene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, IR, and NMR, to ensure high purity and consistent identity suitable for pharmaceutical synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.