Description

Heptafluorobutyryl Chloride is a highly reactive fluorinated acid chloride derivative, serving as a critical building block for introducing the perfluorobutyl moiety into target molecules. Its primary value lies in enabling the synthesis of compounds with enhanced stability, lipophilicity, and unique electronic properties. This reagent is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for creating active ingredients, ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing active pharmaceutical ingredients (APIs) and diagnostic agents, especially those requiring perfluorinated groups for metabolic stability or imaging properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the heptafluorobutyryl group can improve weather resistance and biological activity.
• Derivatization Agent for Analysis: Employed in Gas Chromatography (GC) and Mass Spectrometry (MS) to derivative amines, alcohols, and phenols for improved detection and volatility.
• Polymer & Material Science: Monomer or modifier for creating fluorinated polymers, coatings, and surfactants with superior oil, water, and chemical resistance.
• Ligand & Catalyst Preparation: Facilitates the synthesis of fluorinated ligands used in catalysis and metal-organic frameworks (MOFs).
• Organic Synthesis Building Block: A versatile reagent for acylations and the preparation of amides, esters, and ketones with fluorinated chains in research and development.

Basic Information

Product Name	Heptafluorobutyryl Chloride
CAS No.	375-16-6
Molecular Formula	C4ClF7O
Molecular Weight	232.49 g/mol
Synonyms	Perfluorobutyryl Chloride; 2,2,3,3,4,4,4-Heptafluorobutanoyl Chloride; Heptafluorobutyric Acid Chloride; 4,4,4-Trifluoro-3,3-bis(trifluoromethyl)propionyl Chloride; Perfluorobutanoic Acid Chloride; C3F7COCl; HFB-Cl; NSC 9235
EINECS	206-787-9

Quality Control

Our Heptafluorobutyryl Chloride is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.