Description

2',3'-o-Isopropylideneguanosine is a key protected nucleoside derivative, serving as a vital synthetic intermediate in organic and medicinal chemistry. Its primary value lies in providing a reactive scaffold for the controlled synthesis of more complex nucleoside analogs and oligonucleotides, where protecting the ribose hydroxyl groups is essential. This compound is particularly needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent industries for developing antiviral agents, nucleotide-based therapeutics, and advanced molecular probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA sequences for research and therapeutic applications.
• Biochemical Research: Serves as a precursor for labeled nucleotides used in studies of enzyme mechanisms and nucleic acid metabolism.
• Diagnostic Reagent Production: Employed in manufacturing components for diagnostic kits and molecular probes.
• Academic & R&D Laboratories: Essential for chemical biology research and the development of new nucleotide-based tools.

Basic Information

Product Name	2',3'-o-Isopropylideneguanosine
CAS No.	362-76-5
Molecular Formula	C13H17N5O5
Molecular Weight	323.31 g/mol
Synonyms	9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-2-amino-1,9-dihydro-6H-purin-6-one; Guanosine, 2',3'-O-(1-methylethylidene)-; 2',3'-O-Isopropylideneguanosine; 2',3'-Isopropylidene Guanosine; 2',3'-O-(1-Methylethylidene)guanosine; N2-Acetyl-2',3'-O-isopropylideneguanosine (precursor); Protected Guanosine Derivative
EINECS	Contact for details

Quality Control

Our 2',3'-o-Isopropylideneguanosine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.