Description

2-Hydroxyestrone is a significant endogenous metabolite of estrone, playing a crucial role in estrogen metabolism pathways. This compound is essential for researchers and manufacturers in the pharmaceutical and life sciences sectors, particularly for its relevance in hormone-related studies and diagnostic applications. It is a key material for developing reference standards, biochemical research, and investigating metabolic processes in endocrinology.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development and validation in drug testing and quality control laboratories.
• Biochemical Research: Serves as a critical reagent in studying estrogen metabolism, enzyme activity (e.g., CYP450 enzymes), and hormonal pathways in preclinical research.
• Diagnostic Kit Manufacturing: Employed in the production of calibrators and controls for immunoassays and LC-MS/MS kits designed to measure estrogen metabolites in clinical settings.
• Endocrinology Studies: A vital tool for investigating the biological activity, receptor binding, and physiological effects of estrogen metabolites in academic and institutional research.
• Metabolite Synthesis: Acts as a key intermediate or starting material in the organic synthesis of more complex steroid derivatives and labeled compounds for tracer studies.

Basic Information

Product Name	2-Hydroxyestrone
CAS No.	362-06-1
Molecular Formula	C18H22O3
Molecular Weight	286.36 g/mol
Synonyms	1,3,5(10)-Estratrien-2,3-diol-17-one; 2-OHE1; Estra-1,3,5(10)-triene-2,3,17-triol; 2-Hydroxy-17-oxoestra-1,3,5(10)-trien-3-ol; 2-OH-Estrone; 2-OHE; 2-Hydroxyoestrone
EINECS	Contact for details

Quality Control

Our 2-Hydroxyestrone is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.