Description

2-Hydroxyestradiol is a significant endogenous metabolite of estradiol, playing a crucial role in estrogen metabolism and associated biological pathways. This compound is of high interest in research and development due to its potential biological activity and utility as a reference standard. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic manufacturers for applications in endocrinology, oncology, and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and the validation of methods in drug development and quality control laboratories.
• Biochemical Research: Serves as a key intermediate or substrate in studies investigating estrogen metabolism, receptor binding, and hormonal signaling pathways.
• Diagnostic Kit Development: Employed in the manufacturing and calibration of immunoassay kits for the quantitative measurement of estrogen metabolites in clinical and research settings.
• Metabolite Profiling: Used as an authentic standard in mass spectrometry and chromatography-based metabolomic studies to identify and quantify estrogen derivatives in biological samples.
• Toxicology Studies: Applied in research examining the metabolic fate, bioactivation, and potential toxic effects of estrogenic compounds.

Basic Information

Product Name	2-Hydroxyestradiol
CAS No.	362-05-0
Molecular Formula	C18H24O3
Molecular Weight	288.38 g/mol
Synonyms	Estra-1,3,5(10)-triene-2,3,17β-triol; 2,3,17β-Trihydroxyestra-1,3,5(10)-triene; 2-OHE2; 2-OH-E2; 2-Hydroxy-17β-estradiol; 2,3-Dihydroxyestra-1,3,5(10)-trien-17β-ol
EINECS	Contact for details

Quality Control

Our 2-Hydroxyestradiol is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity determination by HPLC, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.