Description

Fluoroacetyl Chloride CAS NO 359-06-8 is a highly reactive acyl chloride derivative, serving as a critical fluorinated building block in advanced organic synthesis. Its primary value lies in introducing the fluoroacetyl moiety, a key structural feature for modifying the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty materials sectors who require precise fluorination for developing novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing fluorinated active pharmaceutical ingredients (APIs), including potential antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides where fluorine incorporation enhances efficacy and environmental persistence.
• Peptide & Protein Modification: Employed to fluoroacetylate amino groups, creating modified peptides for biochemical research and drug discovery.
• Fluorinated Polymer & Material Science: Acts as a monomer or modifier in the synthesis of specialty polymers with unique surface properties, chemical resistance, or optical characteristics.
• Radiochemistry & Tracer Development: Useful precursor for introducing fluorine-18 or other radioisotopes in Positron Emission Tomography (PET) tracer synthesis.
• Liquid Crystal & Electronic Chemical Production: Building block for creating fluorinated components used in display technologies and electronic materials.

Basic Information

Product Name	Fluoroacetyl Chloride
CAS No.	359-06-8
Molecular Formula	C2H2ClFO
Molecular Weight	96.49 g/mol
Synonyms	2-Fluoroacetyl Chloride; Monofluoroacetyl Chloride; Fluoracetyl Chloride; Acetyl Chloride, 2-fluoro-; 2-Fluoroethanoyl Chloride; α-Fluoroacetyl Chloride; NSC 9245; Fluoroacetic Acid Chloride
EINECS	206-623-7

Quality Control

Our Fluoroacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by GC or titration and impurity profiling, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area, away from heat, ignition sources, and incompatible materials such as strong bases, alcohols, and water. Due to its highly volatile and strong acid/organic solvent nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture ingress and decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.