Description

1,1-Bis-(4-Fluoro-Phenyl)-Prop-2-Yn-1-Ol CAS NO 357-77-7 is a specialized fluorinated organic building block featuring a propargylic alcohol core flanked by two 4-fluorophenyl groups. This compound matters as a versatile intermediate for synthesizing complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the fluorine atoms and alkyne moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Acts as a precursor for sophisticated ligands in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, or organic electronic materials due to its rigid, fluorinated structure.
• Chemical Biology Probes: Utilized to build molecular probes for studying biological processes, leveraging the alkyne group for click chemistry applications.
• Academic & Industrial R&D: A valuable tool for methodological development and exploratory synthesis in organic chemistry laboratories worldwide.

Basic Information

Product Name	1,1-Bis-(4-Fluoro-Phenyl)-Prop-2-Yn-1-Ol
CAS No.	357-77-7
Molecular Formula	C15H10F2O
Molecular Weight	244.24 g/mol
Synonyms	1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol; 1,1-Bis(p-fluorophenyl)-2-propyn-1-ol; 1,1-Di(4-fluorophenyl)-2-propyn-1-ol; 2-Propyn-1-ol, 1,1-bis(4-fluorophenyl)-; α,α-Bis(4-fluorophenyl)-2-propyn-1-ol; 4,4'-Difluorobenzhydryl propargyl alcohol; (4,4'-Difluorophenyl)propargyl carbinol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards and customer-specific requirements. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a strict quality management system to guarantee supply reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; containers must be kept tightly sealed and purged after each use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.