Description

Trifluoroacetyl Chloride CAS NO 354-32-5 is a highly reactive acyl chloride derivative, serving as a critical fluorinated building block in advanced organic synthesis. Its primary value lies in introducing the trifluoroacetyl group, which significantly alters the electronic and metabolic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, enabling the development of novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing active pharmaceutical ingredients (APIs), particularly in the production of fluorinated drugs where it enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to manufacture advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve efficacy and environmental profile.
• Peptide & Protein Modification: Employed as a blocking or modifying agent in peptide synthesis and biochemical research.
• Liquid Crystal & Polymer Chemistry: Acts as a monomer or modifier in the synthesis of fluorinated polymers and advanced materials with unique thermal and chemical resistance.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and other reactions to introduce the -COCF3 moiety into complex organic frameworks.
• Analytical Chemistry: Used as a derivatization agent in gas chromatography and mass spectrometry for the analysis of amines, alcohols, and other compounds.

Basic Information

Product Name	Trifluoroacetyl Chloride
CAS No.	354-32-5
Molecular Formula	C2ClF3O
Molecular Weight	132.47 g/mol
Synonyms	Trifluoroacetic acid chloride; Trifluoroacetic chloride; Perfluoroacetyl chloride; 2,2,2-Trifluoroacetyl chloride; TFAC; TFA-Cl; Trifluoroethanoyl chloride; CF3COCl
EINECS	206-557-1

Quality Control

Our Trifluoroacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing assay, impurity profiles, and physical properties. Our quality commitment ensures the material meets the stringent requirements for research and industrial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong bases, alcohols, and amines. Due to its hygroscopic and highly volatile nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) and handled in a fume hood. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Trifluoroacetic Acid (GC)	≤ 1.0%
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.