Description

5-Trifluoromethyl-2'-Deoxyuridylic Acid is a fluorinated nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer agents, leveraging the unique properties of the trifluoromethyl group to enhance metabolic stability and biological activity. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of next-generation therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and DNA synthesis pathways.
• Pro-drug Development: Serves as a core structure for designing pro-drugs with improved bioavailability and targeted delivery.
• Diagnostic Agent Synthesis: Employed in the creation of labeled compounds for molecular imaging and diagnostic applications.
• Life Science Reagents: Component in high-purity kits and reagents for genetic and cellular research.

Basic Information

Product Name	5-Trifluoromethyl-2'-Deoxyuridylic Acid
CAS No.	345-02-8
Molecular Formula	C10H11F3N2O8P
Molecular Weight	366.17 g/mol
Synonyms	5-Trifluoromethyl-2'-deoxyuridine 5'-monophosphate; 5-Trifluoromethyl-dUMP; 5-CF3-dUMP; Trifluridine monophosphate (related analog); 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione 5'-(dihydrogen phosphate); 5-Trifluoromethyl-2'-deoxyuridylic acid, disodium salt (common salt form); F3C-dUMP
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-2'-Deoxyuridylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the stringent requirements for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.