Description

1-Phenyl-2,2,2-Trifluoroethanol is a versatile fluorinated aromatic alcohol with the CAS number 340-05-6. This compound is a valuable chiral building block and intermediate in organic synthesis, prized for its ability to introduce both aromatic and trifluoroethanol moieties into target molecules. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic structures to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling high enantioselectivity in critical bond-forming reactions.
• Advanced Material Monomer: Incorporated into polymers and specialty chemicals to impart unique properties such as hydrophobicity, chemical resistance, and optical clarity.
• Organic Synthesis Building Block: Employed in nucleophilic substitution, esterification, and oxidation reactions to construct complex molecular architectures in medicinal and process chemistry.
• Research & Development: Utilized in academic and industrial R&D labs for method development, library synthesis, and exploring new chemical entities.

Basic Information

Item	Detail
Product Name	1-Phenyl-2,2,2-Trifluoroethanol
CAS No.	340-05-6
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	α,α,α-Trifluoro-2-phenylethanol; (2,2,2-Trifluoro-1-hydroxyethyl)benzene; 2,2,2-Trifluoro-1-phenylethanol; Benzyl Alcohol, α,α,α-trifluoro-; 1-Phenyl-2,2,2-trifluoroethan-1-ol; α-(Trifluoromethyl)benzyl Alcohol; F3C-CH(OH)-Ph
EINECS	206-419-8

Quality Control

Our 1-Phenyl-2,2,2-Trifluoroethanol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (IR, NMR), to ensure high purity and consistent identity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for production where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Optical Purity (Chiral HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.