Description

4-(Trifluoromethylthio)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing benzoyl chloride group and the lipophilic, metabolically stable trifluoromethylthio moiety, enabling precise molecular modifications. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials that require enhanced bioavailability and chemical stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethylthio group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for electron-transport materials and charge-generating compounds in electronic displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce functional side chains into polymers, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Dye & Pigment Manufacturing: Intermediate for producing specialized dyes and pigments with improved fastness and unique optical properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl structures.

Basic Information

Item	Details
Product Name	4-(Trifluoromethylthio)Benzoyl Chloride
CAS No.	330-14-3
Molecular Formula	C8H4ClF3OS
Molecular Weight	240.63 g/mol
Synonyms	p-(Trifluoromethylthio)benzoyl chloride; 4-(Trifluoromethylsulfanyl)benzoyl chloride; α-Chloro-4-[(trifluoromethyl)thio]benzaldehyde; Benzoyl chloride, 4-[(trifluoromethyl)thio]-; 4-Trifluoromethylthiobenzoyl chloride; 4-(Trifluoromethylmercapto)benzoyl chloride; 4-SCF3 Benzoyl Chloride
EINECS	206-357-5

Quality Control

Our 4-(Trifluoromethylthio)Benzoyl Chloride is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition. Store separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.