Description

Alpha,Alpha,α-Trifluoro-o-Toluoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block for introducing the ortho-trifluoromethylbenzoyl moiety. Its primary value lies in enabling efficient synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used to manufacture advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer chains, enhancing chemical resistance and thermal stability of specialty plastics and coatings.
• Complex Ligand & Catalyst Preparation: Useful in organic synthesis for creating specialized ligands and catalysts used in asymmetric catalysis and cross-coupling reactions.
• Dye & Pigment Manufacturing: Intermediate for producing fluorinated dyes and pigments with improved color fastness and solubility properties.

Basic Information

Product Name	Alpha,Alpha,α-Trifluoro-o-Toluoyl Chloride
CAS No.	329-15-7
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2-(Trifluoromethyl)benzoyl chloride; o-(Trifluoromethyl)benzoyl chloride; 2-Trifluoromethylbenzoyl chloride; α,α,α-Trifluoro-o-toluoyl chloride; 2-(Trifluoromethyl)benzenecarbonyl chloride; TFMBC; o-TFMBC; NSC 404083
EINECS	206-340-9

Quality Control

Our Alpha,Alpha,α-Trifluoro-o-Toluoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.