Description

2-Fluoro-4-Methoxybenzoylchloride is a versatile and reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of both fluorine and methoxy functional groups, enabling precise modulation of electronic and steric properties in target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated mesogens and electron-transport materials in display and lighting technologies.
• Polymer Modification: Employed to introduce functional side chains into polymers, altering thermal, optical, or surface properties for specialty plastics and coatings.
• Peptide & Protein Chemistry: Acts as an acylating agent for modifying amino acids or protecting groups in complex bioconjugation and peptide synthesis workflows.
• Chemical Research & Development: A valuable reagent for medicinal chemistry, process chemistry, and exploring new synthetic methodologies in academic and industrial R&D labs.

Basic Information

Item	Detail
Product Name	2-Fluoro-4-Methoxybenzoylchloride
CAS No.	321-24-4
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	4-Methoxy-2-fluorobenzoyl chloride; 2-Fluoro-4-methoxybenzoic acid chloride; 2-Fluoro-p-anisoyl chloride; 4-Methoxy-2-fluorobenzoic acid chloride; 321-24-4; 2-Fluoro-4-methoxybenzoyl chloride; 2-Fluoro-4-methoxy-benzoic acid chloride; 2-Fluoro-4-methoxybenzoylchloride
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-4-Methoxybenzoylchloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting full specifications are provided with each shipment, supporting compliance in GMP-aligned synthesis and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.