Description

5-Chloro-2-(Trifluoromethyl)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its ability to efficiently introduce the 5-chloro-2-(trifluoromethyl)benzoyl moiety, a key structural motif that imparts desirable properties to target molecules. This intermediate is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl and chloro-substituted aromatic systems for bioactivity and metabolic stability.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Material Production: Used in the manufacture of specialty chemicals for electronic displays and organic light-emitting diodes due to its aromatic and halogenated structure.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of high-performance polymers and resins with specific thermal or chemical resistance properties.
• Dyestuff and Pigment Manufacturing: Intermediate for creating complex organic dyes and pigments with unique color fastness and stability characteristics.
• Custom Synthesis & Contract Research: A valuable reagent for fine chemical companies and CROs/CMOs engaged in custom synthesis and scale-up projects for clients.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Benzoyl Chloride
CAS No.	320-84-3
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	5-Chloro-α,α,α-trifluoro-o-toluoyl chloride; 2-Trifluoromethyl-5-chlorobenzoyl chloride; 5-Chloro-2-(trifluoromethyl)benzoic acid chloride; Benzoyl chloride, 5-chloro-2-(trifluoromethyl)-; 5-Chloro-α,α,α-trifluoro-2-methylbenzoyl chloride
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (IR, NMR), to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with water and strong bases; ensure containers are kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain purity. Keep away from heat, open flames, and incompatible materials such as alcohols, amines, and strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.