Description

5-Fluorouridine is a fluorinated pyrimidine nucleoside analog, a key intermediate in the synthesis of more complex antiviral and anticancer agents. Its modified structure allows it to interfere with nucleic acid synthesis, making it a valuable building block for pharmaceutical research and development. This compound is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the development of nucleoside-based therapeutics and molecular biology studies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potent antiviral and anticancer drugs, such as 5-fluorouracil and related prodrugs.
• Biochemical Research: Used as a tool compound to study RNA metabolism, enzyme inhibition, and the mechanisms of fluoropyrimidines in cellular systems.
• Antiviral Agent Development: Serves as a core scaffold for creating novel nucleoside analogs targeting viral polymerases.
• Oncology Research: Investigated for its role and metabolites in disrupting cancer cell proliferation through incorporation into RNA.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing studies.

Basic Information

Product Name	5-Fluorouridine
CAS No.	316-46-1
Molecular Formula	C9H11FN2O6
Molecular Weight	262.19 g/mol
Synonyms	5-Fluorouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-fluoropyrimidine-2,4-dione; 5-Fluoro-1-β-D-ribofuranosyluracil; 5-FUrd; 5-Fluorouridine, 1-β-D-Ribofuranoside; NSC 52904; 5-Fluorouridine (5-FUrd)
EINECS	206-269-5

Quality Control

Our 5-Fluorouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.