Description

2-(Trifluoromethyl)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the introduction of the reactive acyl chloride group and the electron-withdrawing trifluoromethyl moiety, enabling efficient construction of complex molecules. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing benzamide or aryl ketone scaffolds with trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in manufacturing herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Material Production: Acts as a building block for creating advanced organic electronic materials and liquid crystal compounds.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce aromatic and fluorinated segments into polymer chains, altering material properties.
• Dyestuff and Pigment Manufacturing: Intermediate for synthesizing specialized dyes and pigments with unique color fastness and chemical resistance.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in exploring new reactions and creating novel chemical entities.

Basic Information

Product Name	2-(Trifluoromethyl)Benzoyl Chloride
CAS No.	312-94-7
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2-(Trifluoromethyl)benzoyl chloride; α,α,α-Trifluoro-o-toluoyl chloride; o-(Trifluoromethyl)benzoyl chloride; 2-Trifluoromethylbenzoyl chloride; Benzoyl chloride, 2-(trifluoromethyl)-; o-Trifluoromethylbenzoyl chloride; 2-Trifluoromethylbenzoic acid chloride
EINECS	206-226-3

Quality Control

Our 2-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, and NMR to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. Due to its hygroscopic and highly volatile nature, keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.