Description

Ethyl Dimethylphosphonoacetate is a versatile organophosphorus compound widely used as a key synthetic intermediate. Its primary value lies in its role as a Horner-Wadsworth-Emmons (HWE) reagent, enabling the efficient formation of carbon-carbon double bonds to synthesize α,β-unsaturated esters and other complex molecules. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing olefin linkages in drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators that require specific alkene structures.
• Fine Chemical Manufacturing: Serves as a key building block for synthesizing flavors, fragrances, and other high-value specialty chemicals.
• Material Science Research: Employed in the development of novel polymers, ligands, and organic electronic materials via olefination reactions.
• Academic & R&D Laboratories: A staple reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	Ethyl Dimethylphosphonoacetate
CAS No.	311-46-6
Molecular Formula	C6H13O5P
Molecular Weight	196.14 g/mol
Synonyms	Diethyl (dimethoxyphosphinyl)acetate; (Dimethoxyphosphinyl)acetic acid ethyl ester; Ethyl (dimethoxyphosphinyl)acetate; Acetic acid, 2-(dimethoxyphosphinyl)-, ethyl ester; Diethyl phosphonoacetate (common name); Ethyl 2-(dimethoxyphosphoryl)acetate; EMME reagent derivative; HWE reagent.
EINECS	206-226-7

Quality Control

Our Ethyl Dimethylphosphonoacetate is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to minimize moisture absorption and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.440
Density (20°C)	1.18 - 1.22 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.