Description

Azido-PEG10-NHS Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and an N-hydroxysuccinimide (NHS) ester. This compound is essential for creating stable, site-specific bioconjugates through efficient click chemistry and amine coupling reactions. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and advanced material science for labeling, surface modification, and drug delivery system construction.

Application

• Bioconjugation and Protein Labeling: Site-specific modification of antibodies, peptides, and other biomolecules via copper-free click chemistry.
• ADC (Antibody-Drug Conjugate) Development: Facilitating the construction of linker-payload complexes for targeted cancer therapies.
• Surface Functionalization: PEGylation of nanoparticles, biosensors, and diagnostic chips to introduce azide handles for further coupling.
• Polymer and Material Science: Serving as a key building block for synthesizing functionalized hydrogels and smart biomaterials.
• Diagnostic Reagent Preparation: Conjugating detection probes (e.g., dyes, enzymes) to targeting ligands for assay development.
• Drug Delivery System Optimization: Engineering stealth liposomes and polymeric micelles with targeted surface chemistry.

Basic Information

Product Name	Azido-PEG10-NHS Ester
CAS No.	2801772-86-9
Molecular Formula	C33H60N4O15
Molecular Weight	752.85 g/mol
Synonyms	NHS-PEG10-Azide; Azido-PEG10-NHS Ester; N-(Azido-PEG10)-N-hydroxysuccinimide ester; 11-Azido-3,6,9-trioxaundecan-1-yl 2,5-dioxopyrrolidine-1-carboxylate; PEG10 Azide NHS Ester; Azido-PEG10-OSu; α-Azido-ω-NHS-PEG10; Azido-Polyethylene Glycol10-NHS Ester
EINECS	Contact for details

Quality Control

Every batch of Azido-PEG10-NHS Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure high purity and batch-to-batch consistency. Our quality commitment includes verification of functional group integrity and minimization of impurities like diols and residual solvents. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester moiety is susceptible to hydrolysis. For long-term stability, store under inert atmosphere (argon or nitrogen) and allow the vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.