Description

1-Piperidineethanesulfonic Acid, α-[2-[[4-[(3-Chloro-4-Fluorophenyl)Amino]-7-Methoxy-6-Quinazolinyl]Amino]-2-Oxoethyl]- is a high-purity, advanced pharmaceutical intermediate designed for critical synthesis applications. This compound is essential for research and development in targeted drug discovery, particularly in the development of kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers requiring precise molecular building blocks for novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted kinase inhibitors for oncology research.
• Biochemical Research: Used as a reference standard or precursor in studies of enzyme inhibition and signal transduction pathways.
• Preclinical Development: Serves as a critical starting material for the preparation of candidate drug molecules in early-stage development.
• Fine Chemical Synthesis: Employed in complex multi-step organic syntheses requiring high-fidelity functional group transformations.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	1-Piperidineethanesulfonic Acid, α-[2-[[4-[(3-Chloro-4-Fluorophenyl)Amino]-7-Methoxy-6-Quinazolinyl]Amino]-2-Oxoethyl]-
CAS No.	2641759-50-2
Molecular Formula	C24H27ClFN5O5S
Molecular Weight	543.02 g/mol
Synonyms	α-[2-[[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]amino]-2-oxoethyl]-1-piperidineethanesulfonic acid; PES-Quinazolinyl Amide Derivative; 2641759-50-2; (3-Chloro-4-fluorophenyl)-[7-methoxy-6-({2-oxo-2-[(2-sulfoethyl)amino]ethyl}amino)quinazolin-4-yl]amine 1-piperidine salt; Quinazoline kinase inhibitor intermediate; 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-[[2-oxo-2-(2-sulfoethylamino)ethyl]amino]quinazoline piperidine salt
EINECS	Contact for details

Quality Control

Our 1-Piperidineethanesulfonic Acid derivative is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the stringent requirements for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.