Description

2-Butenamide, n-[4-[(3-Chloro-2-Fluorophenyl)Amino]-7-[2-[(1R,5S)-3-Methyl-3-Azabicyclo[3.1.0]Hex-1-Yl]Ethynyl]-6-Quinazolinyl]-4-(4-Morpholinyl)-, (2E)- is a sophisticated, high-purity organic compound designed for advanced research and development. This molecule is of significant interest as a key intermediate or potential active pharmaceutical ingredient (API) in the discovery of novel therapeutics. It is primarily targeted at pharmaceutical R&D teams and fine chemical manufacturers engaged in developing next-generation kinase inhibitors or other targeted therapies. The compound's complex structure, featuring a quinazoline core and specific stereochemistry, makes it a valuable building block for probing biological pathways.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or reference standard in the synthesis and optimization of novel drug candidates, particularly in oncology and targeted therapy programs.
• Kinase Inhibitor Development: Its structural motifs are characteristic of compounds designed to modulate kinase activity, making it essential for biochemical and cellular assay development.
• Preclinical Studies: Used in pharmacological and toxicological profiling of new chemical entities during the drug discovery pipeline.
• Chemical Biology: Employed as a molecular probe to study specific enzyme-substrate interactions and cellular signaling mechanisms.
• Process Chemistry & Scale-Up: Acts as a benchmark for developing and validating robust, scalable synthetic routes for complex heterocyclic compounds.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in medicinal chemistry and organic synthesis methodologies.

Basic Information

Item	Details
Product Name	2-Butenamide, n-[4-[(3-Chloro-2-Fluorophenyl)Amino]-7-[2-[(1R,5S)-3-Methyl-3-Azabicyclo[3.1.0]Hex-1-Yl]Ethynyl]-6-Quinazolinyl]-4-(4-Morpholinyl)-, (2E)-
CAS No.	2607829-38-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2E)-N-[4-[(3-Chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl]quinazolin-6-yl]-4-morpholin-4-ylbut-2-enamide; 2607829-38-7; UNII-8W2K8S4K4F; 2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-; 8W2K8S4K4F
EINECS	Contact for details

Quality Control

Every batch of this high-value compound is produced and analyzed under strict quality management systems. We provide comprehensive analytical data to support your research, including HPLC purity (typically >95% or custom grades), NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting all critical quality attributes. Our processes are designed to meet the stringent requirements of pharmaceutical R&D, ensuring traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The container should be kept in a dry, well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥95.0% (Custom grades available)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.