Description

Benzenemethanol, 2,6-Difluoro-3-Iodo-α-Methyl- is a highly functionalized aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine and iodine atoms, which provide versatile handles for further derivatization via cross-coupling and nucleophilic substitution reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex molecules where precise halogen substitution is critical.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in fluorinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in constructing advanced herbicides, fungicides, and pesticides where the difluoro and iodo substituents confer specific biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring halogenated aromatic cores.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to form biaryl and other complex structures.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	Benzenemethanol, 2,6-Difluoro-3-Iodo-α-Methyl-
CAS No.	2484889-28-1
Molecular Formula	C8H7F2IO
Molecular Weight	284.05 g/mol
Synonyms	2,6-Difluoro-3-iodo-α-methylbenzyl alcohol; (2,6-Difluoro-3-iodophenyl)ethanol; 1-(2,6-Difluoro-3-iodophenyl)ethanol; α-Methyl-2,6-difluoro-3-iodobenzyl alcohol; 2,6-Difluoro-3-iodo-α-methylbenzenemethanol
EINECS	Contact for details

Quality Control

Every batch of Benzenemethanol, 2,6-Difluoro-3-Iodo-α-Methyl- is manufactured and tested under strict quality management protocols to ensure consistency and purity for critical R&D and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay purity and impurity profiles. Our quality systems are designed to support development from laboratory to pilot plant scale, with documentation suitable for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.