Description

2-Pentenoic Acid, 3-Amino-2-Cyano-5-[(3R,4R)-4-Methyl-3-(Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamino)-1-Piperidinyl]-5-Oxo-, Ethyl Ester, (2E)- is a high-purity, structurally complex organic intermediate of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly those targeting specific enzymatic pathways. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other small-molecule drug candidates.
• Biochemical Research: Used as a reference standard or probe molecule in enzymatic and receptor-binding studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry Development: Serves as a critical intermediate for scaling up the production of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis for clinical trial material production.

Basic Information

Item	Detail
Product Name	2-Pentenoic Acid, 3-Amino-2-Cyano-5-[(3R,4R)-4-Methyl-3-(Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamino)-1-Piperidinyl]-5-Oxo-, Ethyl Ester, (2E)-
CAS No.	2459302-85-1
Molecular Formula	C22H29N7O3
Molecular Weight	439.52 g/mol
Synonyms	(2E)-Ethyl 3-amino-2-cyano-5-[(3R,4R)-4-methyl-3-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]-5-oxo-2-pentenoate; 3-Amino-2-cyano-5-[(3R,4R)-4-methyl-3-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]-5-oxo-2-pentenoic acid ethyl ester (2E)-; Advanced kinase inhibitor intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical characterization, including HPLC, NMR, and LC-MS, to ensure structural identity and high chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, impurity profile, and other critical specifications. We support development under GMP-like conditions for applications requiring the highest standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.