Description

Sivopixant CAS NO 2414285-40-6 is a high-purity, small molecule pharmaceutical compound belonging to the class of P2X3 receptor antagonists. This compound is of significant interest for its targeted therapeutic potential in modulating specific neural pathways. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in preclinical and clinical studies for conditions such as chronic cough and neuropathic pain.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in drug substance and product testing.
• Preclinical Research: Used in in vitro and in vivo studies to investigate the pharmacology, efficacy, and safety profile of P2X3 receptor antagonism.
• Clinical Trial Material (CTM): Supplied as a key active pharmaceutical ingredient (API) or intermediate for the formulation of investigational medicinal products in clinical trials.
• Mechanistic Studies: Employed in biochemical and physiological assays to elucidate the role of P2X3 receptors in various disease states and sensory pathways.
• Drug Discovery & Development: Acts as a critical tool compound for structure-activity relationship (SAR) studies and the discovery of next-generation therapeutics.

Basic Information

Product Name	Sivopixant
CAS No.	2414285-40-6
Molecular Formula	C₂₀H₂₀F₃N₅O₂
Molecular Weight	419.40 g/mol
Synonyms	Sivopixant; BLU-5937; (R)-2-(4-(2-(2-Fluoro-4-(trifluoromethyl)phenyl)propanamido)phenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxamide; P2X3 Receptor Antagonist BLU-5937; (R)-N-(4-(3-Carbamoyl-4,5-dihydro-1H-pyrrolo[1,2-b]pyrazol-2-yl)phenyl)-2-(2-fluoro-4-(trifluoromethyl)phenyl)propanamide
EINECS	Contact for details

Quality Control

Our Sivopixant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. We support compliance with cGMP and ICH Q7 guidelines for APIs intended for investigational use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.