Description

1-Amino-3'-Deoxy-7,8-Dihydro-8-Oxoguanosine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing next-generation nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Pro-drug Development: Employed in the design and synthesis of nucleotide pro-drugs to enhance bioavailability and targeting.
• Antiviral Agent Research: Investigated for its potential activity against a range of viral targets due to its modified nucleoside structure.
• Labeled Compound Synthesis: Can be used to create isotopically labeled versions (e.g., C13, N15) for metabolic tracing and pharmacokinetic studies.

Basic Information

Product Name	1-Amino-3'-Deoxy-7,8-Dihydro-8-Oxoguanosine
CAS No.	2389988-59-2
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	8-Oxo-7,8-dihydro-1-aminoguanosine 3'-deoxy derivative; 1-Amino-3'-deoxy-7,8-dihydro-8-oxoguanosine; 3'-Deoxy-1-amino-7,8-dihydro-8-oxoguanosine; 8-Oxoguanosine derivative, 1-amino-3'-deoxy-7,8-dihydro-; 1-NH2-3'-d-7,8-dihydro-8-oxo-Guo; Modified guanosine analog; Nucleoside research chemical CAS 2389988-59-2
EINECS	Contact for details

Quality Control

Our 1-Amino-3'-Deoxy-7,8-Dihydro-8-Oxoguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.