Description

Mobocertinib Succinate CAS NO 2389149-74-8 is a small molecule kinase inhibitor specifically designed to target epidermal growth factor receptor (EGFR) exon 20 insertion mutations. This compound is of critical importance in the development of targeted cancer therapies for non-small cell lung cancer (NSCLC) patients with this specific genetic alteration. Pharmaceutical research and development organizations, as well as contract manufacturing organizations (CMOs), require this high-purity active pharmaceutical ingredient (API) for preclinical studies, clinical trials, and commercial drug product manufacturing.

Application

• Primary active pharmaceutical ingredient (API) in targeted oncology drug products.
• Key intermediate for research and development of novel tyrosine kinase inhibitor (TKI) therapies.
• Reference standard for analytical method development and validation in quality control laboratories.
• Biochemical tool for in vitro pharmacological studies targeting EGFR mutations.
• Material for preclinical pharmacokinetic and pharmacodynamic (PK/PD) modeling.
• Critical raw material for formulation development of oral solid dosage forms (e.g., tablets, capsules).

Basic Information

Product Name	Mobocertinib Succinate
CAS No.	2389149-74-8
Molecular Formula	C30H34N6O3 • C4H6O4
Molecular Weight	654.73 g/mol (for succinate salt)
Synonyms	TAK-788 Succinate; AP32788 Succinate; Mobocertinib (Succinate); Exkivity (API); (1R,2s)-N-(3-((5-Chloro-4-((1-(cyclopropyl)-1H-pyrazol-4-yl)amino)pyrimidin-2-yl)amino)-4-methylphenyl)-2-fluoro-1-(3-fluorophenyl)cyclopropane-1-carboxamide succinate; EGFR Exon 20 Insertion Inhibitor; TKI Inhibitor TAK-788.
EINECS	Contact for details

Quality Control

Our Mobocertinib Succinate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles as determined by validated methods including HPLC, NMR, and MS. We adhere to cGMP principles where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.