Description

3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-2-Yl)Amino)Piperidin-1-Yl)-3-Oxopropanenitrile is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined molecular architecture. This compound is of critical importance for its role as a key building block in the research and development of novel, targeted therapeutic agents, particularly kinase inhibitors. It is primarily needed by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Kinase Inhibitor Development: Serves as a core scaffold for the design and synthesis of potent and selective kinase inhibitors targeting various disease pathways.
• Oncology Research: Used in the discovery and preclinical development of targeted cancer therapies due to its pyrrolopyrimidine-based structure.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) exploration to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing for clinical trial material (CTM) production.
• Bioconjugation & Prodrug Synthesis: The reactive nitrile and amide functionalities allow for further chemical modifications to create prodrugs or conjugate with targeting moieties.

Basic Information

Product Name	3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-2-Yl)Amino)Piperidin-1-Yl)-3-Oxopropanenitrile
CAS No.	2374700-40-8
Molecular Formula	C17H22N6O
Molecular Weight	326.40 g/mol
Synonyms	(3R,4R)-1-(2-Cyanoacetyl)-4-methyl-N-methyl-N-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)piperidin-3-amine; 3-Oxopropanenitrile, 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-piperidinyl)-; Advanced Kinase Inhibitor Intermediate; Pyrrolopyrimidine-piperidine conjugate; Stereospecific pharmaceutical building block
EINECS	Contact for details

Quality Control

Our 3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-2-Yl)Amino)Piperidin-1-Yl)-3-Oxopropanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.