Description

Bcn-Peg3-Vc-Pfp Ester CAS NO 2353409-45-5 is a specialized bifunctional linker molecule featuring a bicyclo[6.1.0]nonyne (BCN) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a pentafluorophenyl (PFP) ester for efficient amine coupling. This compound is engineered for high-efficiency, copper-free bioconjugation, enabling the stable and selective labeling of biomolecules under mild, physiological conditions. It is an essential reagent for researchers and developers in bioconjugation, proteomics, antibody-drug conjugate (ADC) development, and the synthesis of next-generation diagnostics and therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical bifunctional linker for constructing ADCs, connecting cytotoxic payloads to monoclonal antibodies via its reactive handles.
• Biomolecule Labeling & Profiling: Enables copper-free, site-specific labeling of proteins, peptides, and oligonucleotides for imaging, tracking, and functional studies.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and chemoproteomics to tag and identify enzyme activities in complex biological samples.
• Diagnostic Reagent Synthesis: Facilitates the development of conjugated probes and sensors for in vitro and in vivo diagnostic applications.
• Polymer & Material Science: Acts as a cross-linking agent for modifying surfaces or creating functionalized hydrogels and biomaterials.
• Chemical Biology Tool Development: A key building block for creating novel chemical probes to study biological pathways and interactions.

Basic Information

Product Name	Bcn-Peg3-Vc-Pfp Ester
CAS No.	2353409-45-5
Molecular Formula	C₃₃H₄₀F₅N₃O₈
Molecular Weight	701.69 g/mol
Synonyms	(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-((2-(2-(2,3,5,6-tetrafluoro-4-(2,3,5,6-tetrafluorophenoxy)phenoxy)ethoxy)ethoxy)ethyl)carbamate; BCN-PEG3-VC-PFP ester; BCN-PEG3-Val-Cit-PFP; BCN-PEG3-valine-citrulline-PFP ester; BCN-PEG3-VC-PAB-PFP; BCN-PEG3 protease cleavable linker PFP ester; ADC Linker BCN-PEG3-VC-PFP; Strain-promoted alkyne-PEG3-val-cit-PFP ester
EINECS	Contact for details

Quality Control

Every batch of Bcn-Peg3-Vc-Pfp Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and performance consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards relevant to GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.