Description

Adagrasib is a potent and selective small-molecule inhibitor targeting the KRAS G12C mutation, a key oncogenic driver in several cancers. This high-purity active pharmaceutical ingredient (API) is critical for advancing targeted oncology research and therapeutic development. It is essential for pharmaceutical manufacturers, biotechnology companies, and advanced research institutions engaged in the development of next-generation cancer treatments, particularly for non-small cell lung cancer (NSCLC), colorectal cancer, and pancreatic cancer.

Application

• Primary Active Pharmaceutical Ingredient (API) for the formulation of targeted oncology drugs.
• Critical reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research exploring KRAS G12C inhibition mechanisms.
• Essential material for preclinical and clinical studies investigating new cancer therapies.
• Used in the development of combination therapies to overcome drug resistance in oncology.
• Valuable compound for academic and institutional research into KRAS-driven tumor biology.

Basic Information

Product Name	Adagrasib
CAS No.	2326521-71-3
Molecular Formula	C30H34F2N6O3
Molecular Weight	564.63 g/mol
Synonyms	MRTX849; MRTX 849; MRTX-849; Adagrasib (USAN); (9R)-9-(4-{[(2R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl]carbonyl}piperazin-1-yl)-8-fluoro-2,3-dihydro-1H-[1,4]oxazino[4,3,2-de]phthalazine-5(6H)-one; 8-Fluoro-9-(4-{[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]carbonyl}-1-piperazinyl)-2,3-dihydro-1H-[1,4]oxazino[4,3,2-de]phthalazin-5(6H)-one
EINECS	Contact for details

Quality Control

Our Adagrasib is manufactured under strict quality management systems to meet the rigorous standards required for pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.