Description

Guanosine, 8-Methyl-2'-o-Methyl- is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block and intermediate in the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and oligonucleotide synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of modified oligonucleotides and nucleotide-based prodrugs.
• Antiviral Research: Serves as a building block for developing nucleoside analogs targeting viral polymerases.
• Oncology Drug Discovery: Used in research for creating novel chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed in studies of RNA structure, function, and metabolism due to its specific methylation pattern.
• Proteomics & Genomics: Acts as a specialty reagent in the development of probes and tools for genetic analysis and molecular biology.
• Fine Chemical Synthesis: A valuable intermediate for custom synthesis and contract manufacturing organizations (CMOs) serving the life sciences sector.

Basic Information

Product Name	Guanosine, 8-Methyl-2'-o-Methyl-
CAS No.	2306782-64-7
Molecular Formula	C12H17N5O5
Molecular Weight	311.30 g/mol
Synonyms	8-Methyl-2'-O-methylguanosine; 2'-O-Methyl-8-methylguanosine; 8-Methyl-2'-O-Me-guanosine; N2,2'-O-Dimethylguanosine (ambiguous, check context); 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-8-methyl-3H-purin-6-one; Modified Nucleoside; Guanosine Derivative
EINECS	Contact for details

Quality Control

Our Guanosine, 8-Methyl-2'-o-Methyl- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.