Description

3'-Deoxy-Methyl-2-Thiouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of oligonucleotides and potential therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel antiviral drugs, antisense oligonucleotides, and other RNA-targeting therapeutics. The precise chemical structure of this analog allows for fine-tuning of pharmacokinetic properties and binding affinity in drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical synthon in the production of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified building block in solid-phase synthesis for creating research-grade and therapeutic antisense oligonucleotides (ASOs) and siRNA.
• Biochemical Research: Employed in studies investigating RNA structure, function, and metabolism, including research on tRNA modification and function.
• Medicinal Chemistry: Acts as a scaffold for structure-activity relationship (SAR) studies to develop new therapeutic candidates with improved efficacy and stability.
• Diagnostic Probe Development: Can be utilized in the design and synthesis of labeled probes for detecting specific RNA sequences.

Basic Information

Product Name	3'-Deoxy-Methyl-2-Thiouridine
CAS No.	2305416-19-5
Molecular Formula	C11H16N2O5S
Molecular Weight	288.32 g/mol
Synonyms	2-Thio-3'-deoxymethyluridine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-methoxy-2(1H)-pyrimidinethione; 3'-Deoxy-2-thiomethyluridine; 4-Methoxy-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2(1H)-thione; 2-Thiouridine, 3'-deoxy-, methyl derivative
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-Methyl-2-Thiouridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.