Description

2',3',5'-Tri-o-Benzoyl-5-Hydroxymethyl-2'--C-Methyluridine is a key protected nucleoside intermediate, specifically designed for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity building blocks for the development of modified RNA and DNA analogs. It is essential for pharmaceutical R&D, particularly in the fields of antisense oligonucleotides, siRNA therapeutics, and other nucleic acid-based drug modalities.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside analogs and prodrugs for antiviral and anticancer research.
• Oligonucleotide Synthesis: Used in solid-phase and solution-phase synthesis to introduce specific modifications into RNA and DNA strands, enhancing stability and therapeutic properties.
• Antisense Technology: Serves as a modified monomer for creating antisense oligonucleotides that target specific mRNA sequences.
• siRNA and miRNA Research: Employed in the manufacture of small interfering RNA (siRNA) and microRNA (miRNA) constructs for gene silencing studies and therapeutic development.
• Bioconjugation & Probe Development: Acts as a starting material for synthesizing labeled nucleosides used in diagnostic probes and imaging agents.
• Process Chemistry & Scale-Up: Suitable for GMP-compliant manufacturing processes to produce kilogram-scale quantities for clinical trial materials.

Basic Information

Product Name	2',3',5'-Tri-o-Benzoyl-5-Hydroxymethyl-2'--C-Methyluridine
CAS No.	2305416-16-2
Molecular Formula	C33H30N2O10
Molecular Weight	614.60 g/mol
Synonyms	5-Hydroxymethyl-2'-C-methyluridine 2',3',5'-tribenzoate; 2'-C-Methyl-5-hydroxymethyluridine 2',3',5'-tribenzoate; 2'-C-Methyl-5-(hydroxymethyl)uridine 2',3',5'-tribenzoate; Tribenzoyl-2'-C-methyl-5-hydroxymethyluridine; 2',3',5'-Tri-O-benzoyl-2'-C-methyl-5-(hydroxymethyl)uridine; Protected 2'-C-methyluridine derivative; 2'-C-Me-5-HMUrd(Bz)3
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Benzoyl-5-Hydroxymethyl-2'--C-Methyluridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, residual solvents, and related substances. Our quality commitment ensures material suitable for demanding GMP-grade pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.