Description

3',5'-Di-o-Acetyl-2'-Deoxy-N3-Methyl Uridine is a chemically modified nucleoside derivative, specifically a protected and methylated analog of deoxyuridine. This compound is of significant value as a key synthetic intermediate and building block in advanced organic and medicinal chemistry. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications in oligonucleotide synthesis, prodrug development, and the creation of novel therapeutic agents targeting viral and oncological diseases.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used in the research and development of modified antisense oligonucleotides and siRNA molecules.
• Medicinal Chemistry Research: Serves as a precursor for exploring structure-activity relationships (SAR) in drug discovery programs.
• Biochemical Tool Development: Employed in the creation of labeled probes or substrates for enzymatic studies.
• Academic & Contract Research: Essential for synthetic chemistry projects in universities and contract research organizations (CROs).

Basic Information

Product Name	3',5'-Di-o-Acetyl-2'-Deoxy-N3-Methyl Uridine
CAS No.	2305416-14-0
Molecular Formula	C14H18N2O7
Molecular Weight	326.30 g/mol
Synonyms	2'-Deoxy-N3-methyluridine 3',5'-diacetate; 1-[(2R,4S,5R)-4-Acetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl]-3-methyl-2,4(1H,3H)-pyrimidinedione; N3-Methyl-2'-deoxyuridine 3',5'-diacetate; 3',5'-Di-O-acetyl-N3-methyl-2'-deoxyuridine; 2'-Deoxy-N(3)-methyluridine 3',5'-di-O-acetate
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-2'-Deoxy-N3-Methyl Uridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.