Description

5'-o-Acetyl-5-Acetyloxymethyluridine is a key protected nucleoside derivative, essential for advanced oligonucleotide synthesis and pharmaceutical research. This compound serves as a critical building block, enabling the precise construction of modified RNA and DNA sequences with enhanced stability and functionality. It is primarily utilized by research institutions and manufacturers in the fields of antiviral drug development, therapeutic oligonucleotide production, and diagnostic probe synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase synthesis of modified RNA and DNA strands for therapeutic and diagnostic applications.
• Bioconjugation & Probe Development: Enables the site-specific labeling of nucleic acids with reporter molecules (e.g., fluorophores, biotin) for imaging and detection assays.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and metabolic stability.
• Academic & Institutional Research: Fundamental tool for studying nucleic acid chemistry, enzymology, and molecular biology mechanisms.

Basic Information

Product Name	5'-o-Acetyl-5-Acetyloxymethyluridine
CAS No.	2305416-11-7
Molecular Formula	C15H18N2O9
Molecular Weight	370.31 g/mol
Synonyms	5'-O-Acetyl-5-acetyloxymethyluridine; 5-Acetoxymethyl-2',3',5'-tri-O-acetyluridine (common misnomer check); 5-(Acetoxymethyl)-2',3',5'-tri-O-acetyluridine; 1-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(acetoxymethyl)oxolan-2-yl]-5-(acetoxymethyl)pyrimidine-2,4-dione; Protected 5-Hydroxymethyluridine; 5-HOMU Acetylated Derivative; Nucleoside Building Block CAS 2305416-11-7
EINECS	Contact for details

Quality Control

Our 5'-o-Acetyl-5-Acetyloxymethyluridine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research and cGMP starting material applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.