Description

3'-o-Propargyladenosine is a chemically modified nucleoside derivative, specifically functionalized with a propargyl group at the 3'-hydroxyl position of the ribose sugar. This modification introduces a versatile alkyne handle, making it a critical building block for click chemistry applications, particularly in the synthesis of oligonucleotide conjugates and probes. It is essential for researchers and manufacturers in the fields of pharmaceutical development, bioconjugation, and chemical biology who require precise molecular tools for labeling and functionalizing biomolecules.

Application

• Oligonucleotide Synthesis: Key intermediate for the site-specific incorporation of alkyne groups into DNA or RNA strands for subsequent functionalization.
• Bioconjugation & Probe Development: Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" reactions to attach fluorophores, biotin, or other reporter molecules to nucleic acids.
• Chemical Biology Research: Used to study nucleic acid structure, function, and interactions through bioorthogonal labeling strategies.
• Antiviral & Anticancer Drug Discovery: Serves as a precursor or modified nucleoside analog in the development of novel therapeutic agents.
• Diagnostic Assay Development: Facilitates the creation of highly specific detection probes for PCR, sequencing, and microarray technologies.
• Material Science: Used in the fabrication of functionalized surfaces and nanomaterials for biosensing applications.

Basic Information

Item	Detail
Product Name	3'-o-Propargyladenosine
CAS No.	2305416-10-6
Molecular Formula	C13H15N5O4
Molecular Weight	305.29 g/mol
Synonyms	Adenosine, 3'-O-(2-propynyl)-; 3'-O-Propargyladenosine; 3'-O-(Prop-2-yn-1-yl)adenosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)oxolan-2-yl]-9H-purin-6-amine; Propargyl Adenosine Derivative; Click Chemistry Adenosine Monomer; Alkyne-functionalized Adenosine
EINECS	Contact for details

Quality Control

Our 3'-o-Propargyladenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.