Description

5-Azidomethyl-2'-β-Methyl-2',3',5'-Tri-o-Benzoyluridine is a sophisticated, protected nucleoside derivative designed for advanced synthetic chemistry applications. This compound is a critical building block for the synthesis of modified oligonucleotides, enabling the introduction of specific functional groups into nucleic acid chains. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and agrochemical industries for drug discovery, probe development, and materials science.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of azide-functionalized nucleic acids.
• Click Chemistry: The azido group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and labeling.
• Antisense & siRNA Therapeutics: Used in the research and development of chemically modified oligonucleotides for therapeutic applications.
• Diagnostic Probe Development: Facilitates the creation of labeled probes for fluorescence in situ hybridization (FISH) and other detection assays.
• Materials Science: Serves as a monomer for creating nucleic acid-based polymers and smart materials.
• Academic Research: A valuable tool for studying nucleic acid structure, function, and for developing novel bioorthogonal reactions.

Basic Information

Item	Detail
Product Name	5-Azidomethyl-2'-β-Methyl-2',3',5'-Tri-o-Benzoyluridine
CAS No.	2305416-08-2
Molecular Formula	C33H29N5O9
Molecular Weight	639.62 g/mol
Synonyms	2'-C-Methyl-5-azidomethyluridine 2',3',5'-tribenzoate; 2'-O-Methyl-5-azidomethyluridine tri-benzoate; 5-(Azidomethyl)-2'-C-methyl-2',3',5'-tri-O-benzoyluridine; 2'-β-Methyl-2',3',5'-tri-O-benzoyl-5-azidomethyluridine; 5-Azidomethyl-2'-C-methyl-2',3',5'-tri-O-benzoyl-uridine; Protected 5-azidomethyl-2'-methyluridine; Tribenzoyl-5-azidomethyl-2'-methyluridine
EINECS	Contact for details

Quality Control

Our production of 5-Azidomethyl-2'-β-Methyl-2',3',5'-Tri-o-Benzoyluridine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.