Description

3'-Azido-3'-Deoxy-3-Deazauridine is a chemically modified nucleoside analog of significant interest in medicinal chemistry and biochemical research. This compound serves as a versatile building block and a key intermediate in the synthesis of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on developing nucleoside-based therapeutics. The precise structural modification at the 3'-position with an azido group offers unique reactivity for further chemical elaboration, making it a valuable tool for probing biological mechanisms and creating targeted drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside analog drugs targeting viral polymerases.
• Antiviral Research: Used in biochemical studies to investigate mechanisms of action and develop potential treatments for viral infections.
• Oncology Drug Discovery: Serves as a scaffold for developing prodrugs and targeted therapies aimed at cancer cell proliferation.
• Bioconjugation & Probe Development: The reactive azido group enables click chemistry applications for labeling, imaging, and studying biomolecular interactions.
• Enzyme Inhibition Studies: Employed as a substrate analog to study and inhibit key enzymes like thymidylate synthase or viral reverse transcriptase.
• Academic & Contract Research: A key reagent for universities and CROs conducting fundamental research in nucleotide metabolism and drug design.

Basic Information

Product Name	3'-Azido-3'-Deoxy-3-Deazauridine
CAS No.	2305416-04-8
Molecular Formula	C9H11N5O5
Molecular Weight	269.22 g/mol
Synonyms	3'-Azido-3'-deoxy-3-deazauridine; 1-((2R,3S,4R,5R)-3-Azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2-dihydropyrimidin-2-one; 3-Deaza-3'-azido-3'-deoxyuridine; 3'-N3-3-deaza-dUrd; Azidodeoxydeazauridine
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-3-Deazauridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is hygroscopic and should be handled in a dry environment to prevent moisture uptake. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.