Description

5'(R)-C-Methyl-2-Thiouridine is a high-purity, modified nucleoside building block of significant interest in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of novel oligonucleotides, particularly for applications in antisense therapy and RNA-targeted drug discovery. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in the development of next-generation therapeutics and diagnostic probes.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified RNA strands.
• Antisense & RNA Therapeutics: Used to incorporate specific modifications that enhance stability, binding affinity, and nuclease resistance of therapeutic oligonucleotides.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to RNA metabolism and processing.
• Diagnostic Probe Development: Employed in the creation of high-specificity probes for nucleic acid detection and analysis.
• Medicinal Chemistry: A key intermediate in the discovery and optimization of novel nucleoside analog drugs.
• Academic Research: Used in universities and research institutes for fundamental studies on nucleic acid structure, function, and modification.

Basic Information

Product Name	5'(R)-C-Methyl-2-Thiouridine
CAS No.	2305416-01-5
Molecular Formula	C11H16N2O6S
Molecular Weight	304.32 g/mol
Synonyms	5'-C-Methyl-2-thiouridine (R-isomer); (5'R)-5'-C-Methyl-2-thiouridine; 2-Thio-5'-C-methyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-2-thioxo-1,2-dihydropyrimidin-4(3H)-one; 5'-Methyl-2-thiouridine; Modified Nucleoside; RNA Building Block
EINECS	Contact for details

Quality Control

Our 5'(R)-C-Methyl-2-Thiouridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.