Description

3'-Azido-3'-Deoxy-2-Thiouridine is a modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound matters as a key synthetic intermediate and building block for the creation of novel antiviral and anticancer agents, particularly those targeting RNA-based mechanisms. Researchers and development scientists in the pharmaceutical, biotechnology, and life sciences sectors need this high-purity chemical for probing nucleic acid chemistry and developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to RNA metabolism and viral replication.
• Antiviral Agent Development: Serves as a precursor for compounds targeting viruses such as HIV, Hepatitis C, and other RNA viruses.
• Probe Development: Utilized in the creation of molecular probes for studying nucleic acid structure, function, and interactions.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Labeled Compound Synthesis: Potential starting material for the synthesis of isotopically labeled (e.g., 13C, 15N) analogs for metabolic tracing.

Basic Information

Product Name	3'-Azido-3'-Deoxy-2-Thiouridine
CAS No.	2305416-00-4
Molecular Formula	C9H11N5O5S
Molecular Weight	301.28 g/mol
Synonyms	2-Thio-3'-azido-3'-deoxyuridine; 3'-Azido-2-thiouridine; 3'-N3-2-thio-dU; 1-((2R,3S,5R)-3-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-1,2-dihydropyrimidin-4(3H)-one; 3'-Azido-3'-deoxy-2-thiouridine; AZT-2-thio analog; 2-Thiouridine, 3'-azido-3'-deoxy-
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-2-Thiouridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.