Description

5-Hydroxymethyl-2'--C-Methyluridine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of next-generation nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of modified mRNA components and nucleotide prodrugs.
• Antiviral Research: Investigated for incorporation into oligonucleotides targeting viral polymerases for diseases such as Hepatitis C and SARS-CoV-2.
• Oncology Drug Discovery: Used in the development of nucleoside analogs designed to inhibit cancer cell proliferation.
• Biochemical Tool: Employed in enzymatic studies to understand substrate specificity and mechanism of action of RNA-modifying enzymes.
• Proteomics & Genomics: Acts as a modified base in oligonucleotide synthesis for advanced diagnostic assays and sequencing applications.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.

Basic Information

Product Name	5-Hydroxymethyl-2'--C-Methyluridine
CAS No.	2305415-92-1
Molecular Formula	C11H16N2O7
Molecular Weight	288.26 g/mol
Synonyms	2'-C-Methyl-5-hydroxymethyluridine; 5-(Hydroxymethyl)-2'-C-methyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione; 2'-C-Me-5-HMU; Modified Nucleoside 2305415-92-1
EINECS	Contact for details

Quality Control

Our 5-Hydroxymethyl-2'--C-Methyluridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.