Description

2'-o-Acetyl-5'-o-Benzoyl-3'-o-Methyl-5-Methyluridine is a key protected nucleoside derivative, specifically a modified uridine analog. This compound is essential as a sophisticated building block in the synthesis of oligonucleotides and modified RNA molecules, enabling advanced research and therapeutic development. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on nucleic acid chemistry, antisense technology, and prodrug design.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified RNA strands.
• Antisense & siRNA Research: Used to incorporate specific modifications that enhance stability, binding affinity, and nuclease resistance of therapeutic oligonucleotides.
• Prodrug Development: Serves as an intermediate in the design of nucleoside-based prodrugs for antiviral and anticancer applications.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Bioconjugation & Labeling: The protected functional groups allow for selective deprotection and further chemical modification for probe development.

Basic Information

Product Name	2'-o-Acetyl-5'-o-Benzoyl-3'-o-Methyl-5-Methyluridine
CAS No.	2305415-91-0
Molecular Formula	C21H24N2O8
Molecular Weight	432.43 g/mol
Synonyms	5-Methyl-2'-O-acetyl-5'-O-benzoyl-3'-O-methyluridine; 3'-O-Methyl-2'-O-acetyl-5'-O-benzoyl-5-methyluridine; 2'-Acetyl-5'-benzoyl-3'-methyl-5-methyluridine; N1-[(2R,3R,4R,5R)-4-Acetoxy-5-(benzoyloxymethyl)-3-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione; Protected 5-Methyluridine Derivative; Modified Nucleoside Intermediate
EINECS	Contact for details

Quality Control

Our 2'-o-Acetyl-5'-o-Benzoyl-3'-o-Methyl-5-Methyluridine is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your critical research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.